A missile strike on an industrial area of the central Iranian city of Isfahan has killed at least 15 people, with workers having been inside a factory at the time of the attack, Iranian media reports.

The strike hit a factory producing heating and cooling equipment on Saturday, a working day in Iran, according to the semi-official Fars news agency, which attributed the attack to US and Israeli forces.

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It came on the 15th day of a conflict that Iran’s Ministry of Health says has now killed at least 1,444 people and wounded more than 18,500 since the US-Israeli attacks began on February 28.

Cities across Iran have been repeatedly targeted following the onset of hostilities.

On March 8, shelling damaged Russia’s consulate in Isfahan, injuring staff, with Moscow calling the strike a “blatant violation” of international conventions.

Iran’s Ministry of Culture said on Saturday that 56 museums and historic sites had been damaged, including Naqsh-e Jahan Square, a 17th-century centrepiece of Isfahan, and the UNESCO-listed Golestan Palace in Tehran.

UNESCO said it was “deeply concerned,” noting that four of Iran’s 29 World Heritage Sites had been affected.

Separately on Saturday, Iran’s army confirmed that Brigadier General Abdullah Jalali-Nasab had been killed in an Israeli attack, saying he was “martyred while defending the country”.

Earlier, US forces also struck Kharg Island, which handles roughly 90 percent of Iran’s crude exports, though a regional official said operations were continuing normally, and there were no casualties.

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US President Donald Trump had previously threatened to target the island’s oil infrastructure if Tehran continued to disrupt the Strait of Hormuz.

Any prospect of negotiations appears remote. The Trump administration has rebuffed regional efforts to broker a ceasefire, with a senior White House official telling the Reuters news agency the president is focused on pressing ahead.

“He’s not interested in that right now, and we’re going to continue with the mission unabated,” the official said.

Iran has equally ruled out talks while the attacks continue, Reuters reported, citing an anonymous Iranian official.

Iranian Minister of Foreign Affairs Abbas Araghchi struck a defiant tone on Saturday, saying the US security framework in the region had “proven to be full of holes” and calling on neighbours to “expel foreign aggressors”.

Israeli Minister of Defence Israel Katz said the war was entering a “decisive phase”, which would “continue as long as necessary”.

Iran launched new missile salvoes at Israel on Saturday, with explosions heard over Jerusalem, according to reporters from the AFP news agency.

Six waves of missiles, some carrying cluster bomb warheads, struck wide areas of the country, the Israeli army said. In Eilat, a cluster munition impact injured three people, including a 12-year-old boy, according to The Times of Israel.